منابع مشابه
Chemogenomic profiling predicts antifungal synergies
Chemotherapies, HIV infections, and treatments to block organ transplant rejection are creating a population of immunocompromised individuals at serious risk of systemic fungal infections. Since single-agent therapies are susceptible to failure due to either inherent or acquired resistance, alternative therapeutic approaches such as multi-agent therapies are needed. We have developed a bioinfor...
متن کاملForging synergies in drug discovery.
The pharmaceutical industry, known for its leadership in scientific innovation and as a darling of investors, is currently encountering serious challenges. Increasing costs, a limited drug pipeline, and the impending loss of patent coverage for ‘blockbuster’ drugs are changing the landscape of pharmaceutical science. Though business leadership will be essential to overcome these challenges, the...
متن کاملAntifungal drug resistance.
The increasing incidence of invasive fungal infections is the result of many factors, including an increasing number of patients with severe immunosuppression. Although new drugs have been introduced to combat this problem, the development of resistance to antifungal drugs has become increasingly apparent, especially in patients who require long-term treatment or who are receiving antifungal pr...
متن کاملTarget-Independent Prediction of Drug Synergies Using Only Drug Lipophilicity
Physicochemical properties of compounds have been instrumental in selecting lead compounds with increased drug-likeness. However, the relationship between physicochemical properties of constituent drugs and the tendency to exhibit drug interaction has not been systematically studied. We assembled physicochemical descriptors for a set of antifungal compounds ("drugs") previously examined for int...
متن کاملEfflux-mediated antifungal drug resistance.
Fungi cause serious infections in the immunocompromised and debilitated, and the incidence of invasive mycoses has increased significantly over the last 3 decades. Slow diagnosis and the relatively few classes of antifungal drugs result in high attributable mortality for systemic fungal infections. Azole antifungals are commonly used for fungal infections, but azole resistance can be a problem ...
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ژورنال
عنوان ژورنال: Microbe Magazine
سال: 2012
ISSN: 1558-7452,1558-7460
DOI: 10.1128/microbe.7.233.1